Do I understand correctly in the top of the page poster, that Embryo 3 is optimal for all three phenotypes: IQ 126, Alzheimer's risk 1.8% and T2D risk 11%? If so, it makes sense: T2D is known to accelerate Alzheimer's and higher IQ correlates with lower risk of both diseases.
Is this what the example poster intends to portray?
The idea was just to give a small sample of what an embryo report looks like, where there are typically tradeoffs between the genetic risk of each embryo (some are better on one metric, worse on another). It is not supposed to give any sense that one trait affects another, though you are right that this can happen. Perhaps the most obvious example is intelligence, which can affect how well you deal with addictive tendencies, etc.
Hi Jonathan. As a matter of fact, there is a well known negative correlation between higher IQ and Alzheimer's risk (higher IQ - lower AD risk, while EA by itself when corrected for IQ does not have this correlation), for example here https://academic.oup.com/ije/article/49/4/1163/5719343
No worries, it was not intentional then, but the three embryos showed a statistically likely scenario - this is why it caught my attention - even though the numbers I am sure were made up just for illustration.
Do I understand correctly in the top of the page poster, that Embryo 3 is optimal for all three phenotypes: IQ 126, Alzheimer's risk 1.8% and T2D risk 11%? If so, it makes sense: T2D is known to accelerate Alzheimer's and higher IQ correlates with lower risk of both diseases.
Is this what the example poster intends to portray?
The idea was just to give a small sample of what an embryo report looks like, where there are typically tradeoffs between the genetic risk of each embryo (some are better on one metric, worse on another). It is not supposed to give any sense that one trait affects another, though you are right that this can happen. Perhaps the most obvious example is intelligence, which can affect how well you deal with addictive tendencies, etc.
Hi Jonathan. As a matter of fact, there is a well known negative correlation between higher IQ and Alzheimer's risk (higher IQ - lower AD risk, while EA by itself when corrected for IQ does not have this correlation), for example here https://academic.oup.com/ije/article/49/4/1163/5719343
Also, developing of T2D even mechanistically accelerates many late onset diseases, including AD, strokes, cancers, CAD, etc. Through one of the manifestations of T2D as general metabolic inflammatory state. For example, supplementary review https://dfzljdn9uc3pi.cloudfront.net/2019/7168/1/Article_S1_Corrected2019_07_09.pdf to paper https://doi.org/10.7717/peerj.7168
No worries, it was not intentional then, but the three embryos showed a statistically likely scenario - this is why it caught my attention - even though the numbers I am sure were made up just for illustration.
Great informative post! Cheers.